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Diarmaid Hughes Selected Research

apramycin

10/2022Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
11/2021Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
9/2021Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
1/2019In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.

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Diarmaid Hughes Research Topics

Disease

9Infections
10/2022 - 12/2003
5Urinary Tract Infections (Urinary Tract Infection)
11/2021 - 10/2003
3Bacterial Infections (Bacterial Infection)
01/2021 - 07/2011
3Tuberculosis (Tuberculoses)
11/2013 - 07/2012
2Staphylococcal Infections
01/2021 - 01/2017
2Starvation
11/2018 - 12/2003
2Hypersensitivity (Allergy)
10/2004 - 12/2003
1Pneumonia (Pneumonitis)
10/2022
1Pericarditis
01/2022
1Respiratory Tract Infections (Respiratory Tract Infection)
01/2022
1Injection Site Reaction
01/2022
1Pyelonephritis
11/2021
1Cardiovascular Diseases (Cardiovascular Disease)
02/2021
1Dementia (Dementias)
01/2020
1Cognitive Dysfunction
01/2020
1Hemolysis
09/2018
1Alzheimer Disease (Alzheimer's Disease)
01/2018
1Reinfection
01/2017
1Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis)
02/2016
1Neoplasms (Cancer)
08/2015
1Protozoan Infections
08/2015
1Peritonitis
04/2011
1Bacteremia
05/2009
1Persistent Infection
11/2008
1Wounds and Injuries (Trauma)
08/2005

Drug/Important Bio-Agent (IBA)

9Anti-Bacterial Agents (Antibiotics)IBA
11/2021 - 11/2008
6Pharmaceutical PreparationsIBA
10/2022 - 04/2011
4apramycinIBA
10/2022 - 01/2019
3AminoglycosidesIBA
11/2021 - 01/2017
3Rifampin (Rifampicin)FDA LinkGeneric
02/2016 - 07/2012
2Carbapenems (Carbapenem Antibiotics)IBA
10/2022 - 09/2021
2FluoroquinolonesIBA
06/2005 - 10/2003
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
10/2004 - 12/2003
1rilonaceptFDA Link
01/2022
1InterleukinsIBA
01/2022
1CytokinesIBA
01/2022
1Amikacin (A.M.K)FDA LinkGeneric
11/2021
1AminesIBA
11/2021
1Gentamicins (Gentamicin)FDA LinkGeneric
11/2021
1LipidsIBA
02/2021
1Antihypertensive Agents (Antihypertensives)IBA
01/2020
1Peptide Elongation Factor Tu (EF-Tu)IBA
11/2018
1EstersIBA
09/2018
1Topoisomerase InhibitorsIBA
01/2018
1QuinolonesIBA
01/2018
1Drug CombinationsIBA
04/2013
1DNA-Directed RNA Polymerases (RNA Polymerase)IBA
07/2012
1Dicloxacillin (Dycill)FDA LinkGeneric
04/2011
1Linezolid (Zyvox)FDA Link
04/2011
1Fusidic Acid (Fucithalmic)IBA
05/2009
1Biological ProductsIBA
06/2005
1Ciprofloxacin (Cipro)FDA LinkGeneric
06/2005
1NorfloxacinFDA Link
06/2005
1DNA GyraseIBA
06/2005
1DNA Topoisomerase IV (Topoisomerase IV)IBA
06/2005
1Glutamine (L-Glutamine)FDA Link
10/2004
1Glutamic Acid (Glutamate)FDA Link
10/2004
1Aminolevulinic Acid (Levulan)FDA Link
10/2004
1Heme (Haem)IBA
10/2004
1Amino AcidsFDA Link
10/2004
1Guanosine TetraphosphateIBA
12/2003
1DNA (Deoxyribonucleic Acid)IBA
10/2003

Therapy/Procedure

6Therapeutics
09/2021 - 11/2008
2Drug Therapy (Chemotherapy)
08/2015 - 04/2013
1Phage Therapy
01/2021
1Sutures (Suture)
08/2005